愈创甘油醚增强了对乙酰氨基酚对小鼠的镇痛效力。
Guaifenesin enhances the analgesic potency of paracetamol in mice.
作者信息
Dolezal T, Krsiak M
机构信息
Department of Pharmacology, 3rd Faculty of Medicine, Charles University of Prague, Ruska 87, 100 34 Prague, Czech Republic.
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 2002 Dec;366(6):551-4. doi: 10.1007/s00210-002-0642-y. Epub 2002 Oct 3.
AIM OF INVESTIGATION
Guaifenesin is used as an expectorant and it has been reported to possess muscle relaxant and sedative activity. Guaifenesin has been used as a component of composite OTC analgesics containing paracetamol for many years. The aim of our study was to ascertain effects of guaifenesin on paracetamol analgesic activity and locomotor performance.
METHODS
Antinociceptive efficacy was tested in mice using an acetic acid (0.7%) writhing test. Locomotor performance was tested in rota-rod test and activity cage. All drugs were given orally and tested in mice.
RESULTS
In combination with a subeffective dose of guaifenesin (200 mg/kg), the ED(50) for paracetamol in the writhing test was significantly lower (82.2 mg/kg) than that of paracetamol administered alone (233.7 mg/kg). Guaifenesin alone did not show an analgesic effect. Guaifenesin did not produce statistically significant locomotor impairment in the rota-rod test at doses enhancing analgesic activity of paracetamol, although there was a trend for decreased locomotor activity in activity cage.
CONCLUSION
The present results indicate that guaifenesin may enhance analgesic activity of paracetamol.
研究目的
愈创甘油醚用作祛痰剂，据报道具有肌肉松弛和镇静活性。多年来，愈创甘油醚一直作为含对乙酰氨基酚的复方非处方镇痛药的成分使用。我们研究的目的是确定愈创甘油醚对对乙酰氨基酚镇痛活性和运动能力的影响。
方法
采用乙酸（0.7%）扭体试验在小鼠中测试镇痛效果。在转棒试验和活动笼中测试运动能力。所有药物均经口服给药并在小鼠中进行测试。
结果
在与亚有效剂量的愈创甘油醚（200毫克/千克）联合使用时，对乙酰氨基酚在扭体试验中的半数有效剂量（ED50）显著低于单独给予对乙酰氨基酚时的半数有效剂量（233.7毫克/千克），为82.2毫克/千克。单独使用愈创甘油醚未显示出镇痛效果。在增强对乙酰氨基酚镇痛活性的剂量下，愈创甘油醚在转棒试验中未产生统计学上显著的运动功能损害，尽管在活动笼中有运动活动减少的趋势。
结论
目前的结果表明，愈创甘油醚可能增强对乙酰氨基酚的镇痛活性。
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