小鼠胰腺腺泡细胞中兰尼碱诱导的钙释放的空间特征
Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells.
作者信息
Ashby Michael C, Petersen Ole H, Tepikin Alexei V
机构信息
Medical Research Council Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, UK.
出版信息
Biochem J. 2003 Feb 1;369(Pt 3):441-5. doi: 10.1042/BJ20021039.
Abstract
In pancreatic acinar cells, agonists evoke intracellular Ca(2+) transients which are initiated in the apical region of these polarized cells. There are contradictory experimental data concerning Ca(2+) release from ryanodine receptors (RyRs) in the apical region. In the present study, we have used low doses of ryanodine to open RyRs leading to the release of Ca(2+) from intracellular stores. Ryanodine causes Ca(2+) release that is initiated in the apical region of the cell but is dependent upon functional inositol 1,4,5-trisphosphate receptors (IP(3)Rs). These results suggests that co-ordinated release from co-localized RyRs and IP(3)Rs underlies the increased sensitivity of the apical region to initiation of intracellular Ca(2+) transients.
摘要
在胰腺腺泡细胞中，激动剂可诱发细胞内钙离子瞬变，这种瞬变在这些极化细胞的顶端区域起始。关于顶端区域中兰尼碱受体（RyRs）释放钙离子，存在相互矛盾的实验数据。在本研究中，我们使用低剂量的兰尼碱来开启RyRs，从而导致细胞内钙库释放钙离子。兰尼碱引起的钙离子释放起始于细胞的顶端区域，但依赖于功能性的肌醇1,4,5-三磷酸受体（IP₃Rs）。这些结果表明，共定位的RyRs和IP₃Rs的协同释放是顶端区域对细胞内钙离子瞬变起始敏感性增加的基础。
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