Das Vincent, Nal Béatrice, Roumier Anne, Meas-Yedid Vannary, Zimmer Christophe, Olivo-Marin Jean-Christophe, Roux Pascal, Ferrier Pierre, Dautry-Varsat Alice, Alcover Andrés
Unité de Biologie des Interactions Cellulaires, CNRS URA 1960, Paris, France.
Immunol Rev. 2002 Nov;189:123-35. doi: 10.1034/j.1600-065x.2002.18911.x.
Upon antigen recognition, T cells undergo substantial membrane and cytoskeletal rearrangements that lead to the formation of the immunological synapse and are necessary for subsequent T-cell activation. However, little is known about how membrane and cytoskeletal molecules interact during these processes. Here we discuss the involvement of the membrane-microfilament linker ezrin. We propose that ezrin is a component of the cytoskeleton-mediated architecture of the immunological synapse that plays a role in T-cell receptor clustering, protein kinase C theta translocation and intracellular signaling.
在抗原识别后，T细胞会经历大量的膜和细胞骨架重排，这些重排导致免疫突触的形成，并且对于随后的T细胞活化是必需的。然而，对于这些过程中膜和细胞骨架分子如何相互作用却知之甚少。在这里，我们讨论膜 - 微丝连接蛋白埃兹蛋白（ezrin）的参与情况。我们提出，埃兹蛋白是免疫突触的细胞骨架介导结构的一个组成部分，在T细胞受体聚集、蛋白激酶Cθ易位和细胞内信号传导中发挥作用。
