Marygold Steven J, Leevers Sally J
Growth Regulation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, WC2A 3PX, London, UK.
Curr Biol. 2002 Nov 19;12(22):R785-7. doi: 10.1016/s0960-9822(02)01294-0.
The protein products of the tumor suppressor genes tuberous sclerosis complex 1 and 2 form a protein complex, TSC1-TSC2, that inhibits growth. Several new studies suggest that TSC1-TSC2 does this by inhibiting TOR and S6 kinase, and that PI 3-kinase-Akt signaling relieves this inhibition.
肿瘤抑制基因结节性硬化症复合物1和2的蛋白质产物形成一种蛋白质复合物TSC1 - TSC2，该复合物可抑制生长。几项新的研究表明，TSC1 - TSC2通过抑制TOR和S6激酶来实现这一作用，并且PI 3 - 激酶 - Akt信号传导可解除这种抑制作用。
