Skurkovich S V, Skurkovich B, Kelly J A
Advanced Biotherapy Labs, Rockville, Maryland 20852, USA.
Med Hypotheses. 2002 Dec;59(6):770-80. doi: 10.1016/s0306-9877(02)00346-8.
We pioneered the theory (Nature, 1974) that hyperproduced interferons (cytokines) can bring autoimmune diseases (AD) and neutralizing these cytokines can be therapeutic. In 1975 we first performed successful anticytokine therapy using anti-IFN-alpha antibodies in patients with rheumatoid arthritis (RA). In 1989 we proposed also treating AD including AIDS by removing TNF-alpha and IFN-alpha. Our theory has been widely confirmed: injections of IFN-alpha and -gamma can exacerbate AD, while antibodies to IFN-alpha and -gamma and TNF-alpha can be therapeutic. Anti-IFN-gamma may be a universal treatment for Th1 AD. We had good results using anti-IFN-gamma to treat RA, multiple sclerosis (MS), transplant rejection, alopecia areata, vitiligo, psoriatic arthritis, psoriasis and others. For Th1/Th2 diseases, antagonists to cortisol could prevent the Th1-Th2 shift and allow treatment as a Th1 disease. Anticytokine therapy can also be therapeutic in many neuropsychiatric diseases. Every disturbance of homeostasis may lead to cytokine disturbance. IL-10 may restore homeostasis by inhibiting the production of certain Th1 cytokines and could be used to treat some embryonic disturbances and AD including MS.
我们开创了一种理论（《自然》，1974年），即过量产生的干扰素（细胞因子）可引发自身免疫性疾病（AD），而中和这些细胞因子可能具有治疗作用。1975年，我们首次在类风湿关节炎（RA）患者中使用抗IFN-α抗体成功进行了抗细胞因子治疗。1989年，我们还提出通过去除TNF-α和IFN-α来治疗包括艾滋病在内的AD。我们的理论已得到广泛证实：注射IFN-α和-γ会加重AD，而针对IFN-α、-γ和TNF-α的抗体则具有治疗作用。抗IFN-γ可能是治疗Th1型AD的通用疗法。我们使用抗IFN-γ治疗RA、多发性硬化症（MS）、移植排斥反应、斑秃、白癜风、银屑病关节炎、银屑病等取得了良好效果。对于Th1/Th2疾病，皮质醇拮抗剂可防止Th1-Th2转换，并允许将其作为Th1疾病进行治疗。抗细胞因子疗法在许多神经精神疾病中也具有治疗作用。体内平衡的每一次紊乱都可能导致细胞因子紊乱。IL-10可通过抑制某些Th1细胞因子的产生来恢复体内平衡，并可用于治疗一些胚胎发育紊乱和包括MS在内的AD。
