Marshall M, Sprandel U, Zöllner N
Res Exp Med (Berl). 1975;165(1):61-5. doi: 10.1007/BF01856450.
The intravenous application of 60 mg streptozotocin/kg body weight to a Hanford miniature pig 8 days after a first dose of 30 mg/kg led to a diabetes with loss of insulin response to glucose, hyperglycaemia, glucosuria and a considerable increase of triglycerides and cholesterol. The application of 40 mg streptozotocin/kg to a second pig had no effect.
在给一头汉福德小型猪首次注射30mg/kg链脲佐菌素8天后,静脉注射60mg/kg体重的链脲佐菌素,导致其患糖尿病,出现对葡萄糖的胰岛素反应丧失、高血糖、糖尿以及甘油三酯和胆固醇显著增加的情况。给第二头猪注射40mg/kg链脲佐菌素则没有效果。