Kabashima Hiroaki, Yoneda Masahiro, Nagata Kengo, Hirofuji Takao, Maeda Katsumasa
Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Cytokine. 2002 Oct 21;20(2):70-7. doi: 10.1006/cyto.2002.1985.
Chemokines are said to be small peptides that are chemoattractants for leukocyte subpopulations within local inflammation sites. Gingival inflammation is characterized by infiltration of inflammatory mononuclear cells. The point of this study was to examine the presence or absence of chemokine-positive cells and chemokine receptor-positive cells by means of immunohistochemical methods in samples of gingival tissues obtained from patients with marginal periodontitis. Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, (IFN-gamma)-inducible protein-10 (IP-10) and RANTES-producing cells were found to be present in inflamed human gingival tissues. In addition, CCR5- and CXCR3-positive cells were present. In contrast, no factor expression was observed in periodontally healthy gingival tissue. Our findings suggest that these chemokines may be responsible for modulating the process of infectious disease such as marginal periodontitis.
趋化因子据说是一类小肽，它们是局部炎症部位白细胞亚群的化学引诱剂。牙龈炎症的特征是炎症性单核细胞浸润。本研究的目的是通过免疫组织化学方法，检查从边缘性牙周炎患者获取的牙龈组织样本中趋化因子阳性细胞和趋化因子受体阳性细胞的有无。发现巨噬细胞趋化蛋白-1（MCP-1）、巨噬细胞炎性蛋白（MIP）-1α、MIP-1β、（γ干扰素）诱导蛋白-10（IP-10）以及产生RANTES的细胞存在于发炎的人牙龈组织中。此外，还存在CCR5和CXCR3阳性细胞。相比之下，在牙周健康的牙龈组织中未观察到因子表达。我们的研究结果表明，这些趋化因子可能在调节诸如边缘性牙周炎等传染病的进程中发挥作用。
