Derouiche A, Anlauf E, Aumann G, Mühlstädt B, Lavialle M
Institute of Anatomy, University of Dresden, Fetscherstr 74, D-01307 Dresden, Germany.
J Physiol Paris. 2002 Apr-Jun;96(3-4):177-82. doi: 10.1016/s0928-4257(02)00004-9.
Amongst several forms of glia-neuronal communication, glia-synaptic interaction appears particularly interesting in the light of the well-known examples of two-way signaling between neurons and astrocytes. We review recent structural and physiological evidence showing that the structural correlate of glia-synaptic interaction is the peripheral astrocyte process (PAP) positioned next to the synaptic cleft. The structural and functional properties of these processes suggest that the PAP represents a separate astroglial compartment, in particular since it is characterized by the restricted localization of the actin-binding ERM protein ezrin. The structural properties of PAPs and this protein form the basis of rapid morphological changes of PAPs. The physiological relevance of PAP plasticity is illustrated by the example of the suprachiasmatic nucleus, where astrocytes display a high degree of activity-dependent plasticity reflecting circadian time.
在多种形式的神经胶质细胞与神经元的通讯中，鉴于神经元与星形胶质细胞之间双向信号传导的著名例子，神经胶质细胞与突触的相互作用显得尤为有趣。我们回顾了最近的结构和生理学证据，这些证据表明神经胶质细胞与突触相互作用的结构关联物是位于突触间隙旁的外周星形胶质细胞突起（PAP）。这些突起的结构和功能特性表明，PAP代表一个独立的星形胶质细胞区室，特别是因为它的特征是肌动蛋白结合ERM蛋白埃兹蛋白的定位受限。PAP的结构特性和这种蛋白质构成了PAP快速形态变化的基础。视交叉上核的例子说明了PAP可塑性的生理相关性，在那里星形胶质细胞表现出高度的活动依赖性可塑性，反映昼夜节律时间。
