Kang Tae Cheon, Park Seung Kook, Hwang In Koo, An Sung Jin, Bahn Jae Hoon, Kim Dae Won, Choi Soo Young, Kwon Oh Shin, Baek Nam In, Lee Hyeon Yong, Won Moo Ho
Department of Anatomy, College of Medicine, College of Life Science, Hallym University, Kangwon-Do, Chunchon, South Korea.
Brain Res. 2002 Dec 13;957(2):242-50. doi: 10.1016/s0006-8993(02)03566-7.
To identify the roles of pyridoxal kinase (PLK) in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PLK expression in the gerbil hippocampus was conducted. PLK immunoreactivity in a pre-seizure group of seizure sensitive (SS) gerbils was more strongly detected than that in a seizure resistant (SR) group. The density of PLK immunoreactivity in a 30-min postictal group was significantly lower than that of a pre-seizure group. In a 12 h postictal group, PLK immunodensity recovered to pre-seizure level. The over-expression of PLK in the hippocampus of pre-seizure SS gerbils suggests that PLP play an important role in the modulation of GAD activity and GABA reuptake as mediated by membrane transporter via neurons.
为了确定吡哆醛激酶（PLK）在癫痫发生中的作用以及自发性癫痫发作后的恢复机制，对沙鼠海马中PLK的表达进行了时间顺序和比较分析。癫痫敏感（SS）沙鼠癫痫发作前组中的PLK免疫反应性比癫痫抗性（SR）组中检测到的更强。发作后30分钟组中PLK免疫反应性的密度显著低于发作前组。在发作后12小时组中，PLK免疫密度恢复到发作前水平。癫痫发作前SS沙鼠海马中PLK的过表达表明，磷酸吡哆醛通过神经元经由膜转运体介导在调节GAD活性和GABA再摄取中起重要作用。
