Vandepoele Klaas, Simillion Cedric, Van de Peer Yves
Dept of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, K.L. Ledeganckstraat 35, B-9000, Ghent, Belgium.
Trends Genet. 2002 Dec;18(12):606-8. doi: 10.1016/s0168-9525(02)02796-8.
Genome analysis shows that large-scale gene duplications have occurred in fungi, animals and plants, creating genomic regions that show similarity in gene content and order. However, the high frequency of gene loss reduces colinearity resulting in duplicated regions that, in the extreme, no longer share homologous genes. Here, we show that by comparison with an appropriate second genome, such paralogous regions can still be identified.
基因组分析表明，真菌、动物和植物中都发生过大规模的基因复制，形成了在基因含量和顺序上具有相似性的基因组区域。然而，基因丢失的高频率降低了共线性，导致复制区域在极端情况下不再共享同源基因。在这里，我们表明，通过与合适的第二个基因组进行比较，仍然可以识别出这些旁系同源区域。
