Demirbaş Berrin, Güler Serdar, Cakir Bekir, Culha Cavit, Aral Yalçin
Ankara Education and Research Hospital, Department of Endocrinology, Ankara, Turkey.
Horm Res. 2002;58(6):283-6. doi: 10.1159/000066447.
Tumor necrosis factor-alpha (TNF-alpha) is associated with insulin resistance in certain conditions. However, whether TNF-alpha is related to insulin resistance in hypertensive subjects is still controversial. The aim of this study was to determine the status of TNF-alpha and insulin resistance in hypertension.
Newly diagnosed nondiabetic 17 essentially hypertensive (6 men, 11 women) patients, and 11 control healthy subjects (5 men, 6 women) are involved in the study. Body mass index (BMI), insulin, fasting blood glucose, cholesterol, triglyceride, and TNF-alpha levels were measured. Insulin resistance is assessed according to homeostasis model of assessment (HOMA-IR).
Serum insulin (8.4 +/- 2.7 vs. 6.1 +/- 1.4 mIU/ml; p < 0.01), triglyceride (245.0 +/- 39.9 vs. 193.0 +/- 22.8 mg/dl; p < 0.01), and TNF-alpha (4.2 +/- 0.7 vs. 3.0 +/- 0.6 pg/ml; p < 0.001) levels, and HOMA-IR (2.0 +/- 0.8 vs. 1.3 +/- 0.3; p < 0.001) were significantly higher in the hypertensive patients compared to the normotensive control group. There were positive correlations between TNF-alpha levels and body mass index (r = 0.64, p < 0.01), and triglyceride (r = 0.55 p = 0.02) levels in the whole study group. However, there was no correlation of either TNF-alpha or HOMA-IR.
Our data revealed that hypertensive patients have insulin resistance and higher TNF-alpha levels, but there is no relation between TNF-alpha levels and insulin resistance.
肿瘤坏死因子-α（TNF-α）在某些情况下与胰岛素抵抗相关。然而，TNF-α是否与高血压患者的胰岛素抵抗有关仍存在争议。本研究的目的是确定高血压患者中TNF-α和胰岛素抵抗的状况。
本研究纳入了17例新诊断的非糖尿病原发性高血压患者（6例男性，11例女性）和11例健康对照者（5例男性，6例女性）。测量了体重指数（BMI）、胰岛素、空腹血糖、胆固醇、甘油三酯和TNF-α水平。根据稳态模型评估（HOMA-IR）来评估胰岛素抵抗。
与血压正常的对照组相比，高血压患者的血清胰岛素水平（8.4±2.7对6.1±1.4 mIU/ml；p<0.01）、甘油三酯水平（245.0±39.9对193.0±22.8 mg/dl；p<0.01）、TNF-α水平（4.2±0.7对3.0±0.6 pg/ml；p<0.001）和HOMA-IR（2.0±0.8对1.3±0.3；p<0.001）显著更高。在整个研究组中，TNF-α水平与体重指数（r = 0.64，p<0.01）和甘油三酯水平（r = 0.55，p = 0.02）之间存在正相关。然而，TNF-α与HOMA-IR之间均无相关性。
我们的数据显示高血压患者存在胰岛素抵抗且TNF-α水平较高，但TNF-α水平与胰岛素抵抗之间并无关联。
