非糖尿病高血压患者的血浆肿瘤坏死因子-α水平与胰岛素抵抗

Plasma tumor necrosis factor-alpha levels and insulin resistance in nondiabetic hypertensive subjects.

作者信息

Demirbaş Berrin, Güler Serdar, Cakir Bekir, Culha Cavit, Aral Yalçin

机构信息

Ankara Education and Research Hospital, Department of Endocrinology, Ankara, Turkey.

出版信息

Horm Res. 2002;58(6):283-6. doi: 10.1159/000066447.

DOI:10.1159/000066447

PMID:12446992

Abstract

OBJECTIVES

Tumor necrosis factor-alpha (TNF-alpha) is associated with insulin resistance in certain conditions. However, whether TNF-alpha is related to insulin resistance in hypertensive subjects is still controversial. The aim of this study was to determine the status of TNF-alpha and insulin resistance in hypertension.

METHODS

Newly diagnosed nondiabetic 17 essentially hypertensive (6 men, 11 women) patients, and 11 control healthy subjects (5 men, 6 women) are involved in the study. Body mass index (BMI), insulin, fasting blood glucose, cholesterol, triglyceride, and TNF-alpha levels were measured. Insulin resistance is assessed according to homeostasis model of assessment (HOMA-IR).

RESULTS

Serum insulin (8.4 +/- 2.7 vs. 6.1 +/- 1.4 mIU/ml; p < 0.01), triglyceride (245.0 +/- 39.9 vs. 193.0 +/- 22.8 mg/dl; p < 0.01), and TNF-alpha (4.2 +/- 0.7 vs. 3.0 +/- 0.6 pg/ml; p < 0.001) levels, and HOMA-IR (2.0 +/- 0.8 vs. 1.3 +/- 0.3; p < 0.001) were significantly higher in the hypertensive patients compared to the normotensive control group. There were positive correlations between TNF-alpha levels and body mass index (r = 0.64, p < 0.01), and triglyceride (r = 0.55 p = 0.02) levels in the whole study group. However, there was no correlation of either TNF-alpha or HOMA-IR.

CONCLUSIONS

Our data revealed that hypertensive patients have insulin resistance and higher TNF-alpha levels, but there is no relation between TNF-alpha levels and insulin resistance.

摘要

目的

肿瘤坏死因子-α（TNF-α）在某些情况下与胰岛素抵抗相关。然而，TNF-α是否与高血压患者的胰岛素抵抗有关仍存在争议。本研究的目的是确定高血压患者中TNF-α和胰岛素抵抗的状况。

方法

本研究纳入了17例新诊断的非糖尿病原发性高血压患者（6例男性，11例女性）和11例健康对照者（5例男性，6例女性）。测量了体重指数（BMI）、胰岛素、空腹血糖、胆固醇、甘油三酯和TNF-α水平。根据稳态模型评估（HOMA-IR）来评估胰岛素抵抗。

结果

与血压正常的对照组相比，高血压患者的血清胰岛素水平（8.4±2.7对6.1±1.4 mIU/ml；p<0.01）、甘油三酯水平（245.0±39.9对193.0±22.8 mg/dl；p<0.01）、TNF-α水平（4.2±0.7对3.0±0.6 pg/ml；p<0.001）和HOMA-IR（2.0±0.8对1.3±0.3；p<0.001）显著更高。在整个研究组中，TNF-α水平与体重指数（r = 0.64，p<0.01）和甘油三酯水平（r = 0.55，p = 0.02）之间存在正相关。然而，TNF-α与HOMA-IR之间均无相关性。