初始焦虑-恐惧水平各异的大鼠实验性抑郁-疼痛综合征：一项行为学研究。

Experimental depressive-pain syndrome in rats with initial various anxiety-phobic levels: a behavioral study.

作者信息

Krupina N A, Orlova I N, Khlebnikova N N, Grafova V N, Smirnova V S, Kukushkin M L, Kryzhanovskii G N, Pankova N B, Rodina V I

机构信息

Laboratory of General Pathophysiology of Nervous System, Moscow.

出版信息

Bull Exp Biol Med. 2002 Jun;133(6):548-52. doi: 10.1023/a:1020217421991.

DOI:10.1023/a:1020217421991

PMID:12447461

Abstract

Modeling of neurogenic pain syndrome by sciatic nerve transection in rats with pronounced dopamine-deficiency-dependent 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-induced experimental depressive syndrome forms a stable state of combined pain and depression, which can be considered as a model of the pain-depressive syndrome. The neurogenic pain syndrome prolongs the state of behavioral depression in rats irrespective of their initial anxiety level. The depressive symptoms can potentiate the severity of pain syndrome. By a number of indices, more pronounced behavioral changes during the development of pain-depressive syndrome occur in initially nonanxious rats.

摘要

在具有明显多巴胺缺乏依赖性1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的实验性抑郁综合征的大鼠中，通过坐骨神经横断术对神经源性疼痛综合征进行建模，形成了疼痛与抑郁合并的稳定状态，这可被视为疼痛-抑郁综合征的模型。无论大鼠最初的焦虑水平如何，神经源性疼痛综合征都会延长其行为抑郁状态。抑郁症状会加重疼痛综合征的严重程度。从一些指标来看，最初无焦虑的大鼠在疼痛-抑郁综合征发展过程中出现的行为变化更为明显。