人类表皮中胸腺素含量的年龄相关变化。

Age-related changes of thymalin content in human epidermis.

作者信息

Khlystova Z S, Kalinina I I, Shmeleva S P, Ryabchikov O P, Khavinson V Kh

机构信息

Department of Embryonic Histogenesis, Research Institute of Human Morphology, Moscow.

出版信息

Bull Exp Biol Med. 2002 Jun;133(6):620-2. doi: 10.1023/a:1020214816056.

DOI:10.1023/a:1020214816056

PMID:12447484

Abstract

Immunomorphological analysis revealed the presence of thymalin in human epidermis and in fetal reticuloepithelium. These structures are developed from the common embryonic primordium ectoderm. In embryos and adult humans thymalin is present only in young epidermal cells, which undergo age-related involution. By the age of 70 years, the layer of thymalin-containing cells looks thinned and discontinuous. The content of thymalin, a thymic factor, decreases with age.

摘要

免疫形态学分析显示，胸腺素存在于人类表皮和胎儿网状上皮中。这些结构由共同的胚胎原基外胚层发育而来。在胚胎和成年人体内，胸腺素仅存在于年轻的表皮细胞中，这些细胞会经历与年龄相关的退化。到70岁时，含胸腺素的细胞层看起来变薄且不连续。胸腺素作为一种胸腺因子，其含量会随着年龄的增长而降低。