Omura K, Takahashi M, Omura T, Miyamoto S, Kushida K, Sano Y, Miura M, Nagano A
Hamamatsu University School of Medicine, Hamamatsu, Japan.
Clin Rheumatol. 2002 Nov;21(6):488-92. doi: 10.1007/s100670200120.
Matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) have been reported to be associated with arthritis. Total joint replacement results in total resection of cartilage and synovium at the joint. We investigated longitudinal changes in plasma MMP and TIMP after total joint replacement. Eight patients with osteoarthritis (OA) and 15 patients with rheumatoid arthritis (RA) had total knee or total hip replacements. Plasma was collected from all patients before surgery and at 1 week and 6 weeks after surgery. In RA patients the plasma MMP-3 and the MMP-3/TIMP-1 ratio decreased after total joint replacement, whereas CRP and ESR did not change. Therefore, CRP and ESR reflect systemic inflammation; however, plasma MMP-3 and the MMP-3/TIMP-1 ratio may reflect inflammation and/or degeneration of the affected joint.
据报道，基质金属蛋白酶（MMP）和金属蛋白酶组织抑制剂（TIMP）与关节炎有关。全关节置换术会导致关节处的软骨和滑膜被完全切除。我们研究了全关节置换术后血浆MMP和TIMP的纵向变化。8例骨关节炎（OA）患者和15例类风湿关节炎（RA）患者接受了全膝关节或全髋关节置换术。在手术前以及手术后1周和6周采集所有患者的血浆。在RA患者中，全关节置换术后血浆MMP-3和MMP-3/TIMP-1比值下降，而CRP和ESR没有变化。因此，CRP和ESR反映全身炎症；然而，血浆MMP-3和MMP-3/TIMP-1比值可能反映受影响关节的炎症和/或退变。
