Hahn Judith A, Page-Shafer Kimberly, Lum Paula J, Bourgois Philippe, Stein Ellen, Evans Jennifer L, Busch Michael P, Tobler Leslie H, Phelps Bruce, Moss Andrew R
Department of Epidemiology, University of California, San Francisco, 94110, USA.
J Infect Dis. 2002 Dec 1;186(11):1558-64. doi: 10.1086/345554. Epub 2002 Nov 4.
The present study examined reasons for the high incidence of hepatitis C virus (HCV) infection among young injection drug users (IDUs). IDUs <30 years old who tested negative for HCV antibody were enrolled in a prospective cohort. Risk factors for seroconversion were examined using time-dependent regression analyses: 48 of 195 IDUs seroconverted to HCV, for an incidence rate of 25.1/100 person-years (95% confidence interval, 18.7-32.9/100 person-years). Independent risk factors included sharing needles with an HCV-infected sex partner (borderline statistical significance, P=.11) or a person who was not a sex partner, sharing nonsterile drug-preparation equipment, pooling money with another IDU to buy drugs, and exchanging sex for money. Ubiquitous behaviors among young IDUs, such as the forming of injecting or sexual partnerships and consequent sharing of needles and drug preparation equipment, are risk factors for HCV. Interventions to reduce HCV transmission must recognize the importance of relationships on injecting risk.
本研究调查了年轻注射吸毒者（IDU）中丙型肝炎病毒（HCV）感染率高的原因。年龄小于30岁且HCV抗体检测呈阴性的IDU被纳入一项前瞻性队列研究。使用时间依赖性回归分析来研究血清转化的危险因素：195名IDU中有48人血清转化为HCV，发病率为25.1/100人年（95%置信区间，18.7 - 32.9/100人年）。独立危险因素包括与HCV感染的性伴侣（边缘统计学意义，P = 0.11）或非性伴侣共用针头、共用未消毒的毒品制备设备、与另一名IDU凑钱买药以及以性换钱。年轻IDU中普遍存在的行为，如形成注射或性伴侣关系以及随之而来的共用针头和毒品制备设备，是HCV的危险因素。减少HCV传播的干预措施必须认识到人际关系对注射风险的重要性。
