Madeleine Margaret M, Brumback Babette, Cushing-Haugen Kara L, Schwartz Stephen M, Daling Janet R, Smith Anajane G, Nelson J Lee, Porter Peggy, Shera Katherine A, McDougall James K, Galloway Denise A
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle 98109-1024, USA.
J Infect Dis. 2002 Dec 1;186(11):1565-74. doi: 10.1086/345285. Epub 2002 Nov 4.
The critical role of the human leukocyte antigen (HLA) system in presenting peptides to antigen-specific T cell receptors may explain why only some human papillomavirus (HPV)-infected women progress to cervical cancer. HLA class II DRB1 and DQB1 genes were examined in 315 women with invasive squamous cell cervical cancer (SCC) and 381 control subjects. Increased risks of SCC were associated with DRB11001, DRB11101, and DQB10301, and decreased risks were associated with DRB10301 and DRB113. Of squamous cell tumors, those containing HPV-16 were different from those not containing HPV-16 for 3 alleles: DRB10401, DRB107, and DQB106. Increased risks of SCC were associated with DRB10401-DQB10301 (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.1-2.7) and DRB11101-DQB10301 (OR, 2.5; 95% CI, 1.4-4.5), and decreased risks were associated with DRB10301-DQB102 (OR, 0.7; 95% CI, 0.5-1.0) and DRB113-DQB106 (OR, 0.6; 95% CI, 0.4-0.9) haplotypes. These results add to the evidence that certain HLA class II alleles or allele combinations, or genes linked to them, make some women more susceptible to SCC.
人类白细胞抗原（HLA）系统在将肽段呈递给抗原特异性T细胞受体方面发挥的关键作用，或许可以解释为什么只有部分感染人乳头瘤病毒（HPV）的女性会发展为宫颈癌。研究人员对315名浸润性宫颈鳞状细胞癌（SCC）女性患者和381名对照受试者的HLA II类DRB1和DQB1基因进行了检测。SCC风险增加与DRB11001、DRB11101和DQB10301相关，而风险降低则与DRB10301和DRB113相关。在鳞状细胞瘤中，含有HPV - 16的肿瘤与不含有HPV - 16的肿瘤在3个等位基因上存在差异：DRB10401、DRB107和DQB106。SCC风险增加与DRB10401 - DQB10301（优势比[OR]，1.7；95%置信区间[CI]，1.1 - 2.7）和DRB11101 - DQB10301（OR，2.5；95% CI，1.4 - 4.5）相关，而风险降低与DRB10301 - DQB102（OR，0.7；95% CI，0.5 - 1.0）和DRB113 - DQB106（OR，0.6；95% CI，0.4 - 0.9）单倍型相关。这些结果进一步证明，某些HLA II类等位基因或等位基因组合，或与之相关的基因，会使一些女性更容易患SCC。
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