人类白细胞抗原等位基因（HLA-A、HLA-B 和 HLA-DRB1）与急性淋巴细胞白血病（ALL）相关：伊朗人群样本的病例对照研究。
Human Leukocyte Antigen Alleles (HLA-A, HLA-B, and HLA-DRB1) are associated with Acute Lymphoblastic Leukemia (ALL) : A Case-Control Study in a Sample of Iranian Population.
机构信息
Student of Research Committee, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
Asian Pac J Cancer Prev. 2024 May 1;25(5):1507-1513. doi: 10.31557/APJCP.2024.25.5.1507.
OBJECTIVE
This study seeks to elucidate the association between HLA-A, HLA-B, and HLA-DRB1 alleles and their relative risk contributions to ALL within an Iranian cohort.
METHODS
Utilizing a robust case-control design, this research involved 71 ALL patients and 71 age and sex-matched healthy individuals. Genotyping of specified HLA alleles was performed using the advanced PCR-SSP technique.
RESULTS
Our findings reveal a marked increase in the prevalence of the HLA-DRB104 allele among patients diagnosed with ALL compared to the control group (P<0.027). Conversely, the alleles HLA-A26 (P=0.025), HLA-A33 (P=0.020), and HLA-DRB103 (P=0.035) were observed at significantly reduced frequencies within the patient population.
CONCLUSION
Our findings highlight HLA-DRB104 as a potential genetic marker for increased susceptibility to ALL, while HLA-A26, HLA-A33, and HLA-DRB103 emerge as protective factors.
目的
本研究旨在阐明伊朗队列中 HLA-A、HLA-B 和 HLA-DRB1 等位基因与 ALL 之间的关联及其相对风险贡献。
方法
本研究采用了稳健的病例对照设计，纳入了 71 名 ALL 患者和 71 名年龄和性别匹配的健康个体。使用先进的 PCR-SSP 技术对特定 HLA 等位基因进行基因分型。
结果
我们的研究结果显示，与对照组相比，ALL 患者中 HLA-DRB104 等位基因的患病率显著增加（P<0.027）。相反，在患者群体中，HLA-A26（P=0.025）、HLA-A33（P=0.020）和 HLA-DRB103（P=0.035）等位基因的频率显著降低。
结论
我们的研究结果强调了 HLA-DRB104 作为 ALL 易感性增加的潜在遗传标志物，而 HLA-A26、HLA-A33 和 HLA-DRB103 则作为保护因素出现。
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