用RNA对“进化发育生物学”进行建模。
Modelling 'evo-devo' with RNA.
作者信息
Fontana Walter
机构信息
Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA.
出版信息
Bioessays. 2002 Dec;24(12):1164-77. doi: 10.1002/bies.10190.
PMID:12447981
Abstract
The folding of RNA sequences into secondary structures is a simple yet biophysically grounded model of a genotype-phenotype map. Its computational and mathematical analysis has uncovered a surprisingly rich statistical structure characterized by shape space covering, neutral networks and plastogenetic congruence. I review these concepts and discuss their evolutionary implications.
摘要
RNA序列折叠成二级结构是一种简单但基于生物物理学的基因型-表型图谱模型。对其进行的计算和数学分析揭示了一种惊人丰富的统计结构，其特征包括形状空间覆盖、中性网络和塑性发生一致性。我将回顾这些概念并讨论它们的进化意义。
Zotero 插件