Kowalski C, Roliński Z, Zań R, Wawron W
Department of Pharmacology, Agricultural University, Akademicka 12, 20-033 Lublin, Poland.
Pol J Vet Sci. 2002;5(3):127-30.
Biological availability and pharmacokinetic properties of tylosin were determined in broiler chickens after oral (p.o.) and intravenous (i.v.) administration at a dose of 10 mg/kg. The calculated bioavailability--F%, by comparing AUC values--p.o. and AUC--i.v., ranged from 30%-34%. After intravenous injection tylosin was rapidly distributed in the organism, showing elimination half-life (t1/2 beta) values of 0.52 h and distribution volume (Vd) of 0.69 L/kg, at a clearance rate (Cl) of 5.30 +/- 0.59 ml/min/kg. After oral administration, tylosin has a similar distribution volume (Vd = 0.85 L/kg), while the elimination half-life t1/2 beta of 2.07 h was four times bigger than after i.v. administration at Cl = 4.40 +/- 0.27 ml/min/kg. The obtained value tmax = 1.5 h for tylosin after oral administration indicates that using this antibiotic with drinking water in broiler chickens is the method of choice. However, a relatively low value Cmax = 1.2 micrograms/ml after oral administration of tylosin shows that dosing of this antibiotic in broiler chickens should be higher than in other food producing animals.
以10mg/kg的剂量对肉鸡进行口服（p.o.）和静脉注射（i.v.）给药后，测定了泰乐菌素的生物利用度和药代动力学特性。通过比较口服给药的AUC值和静脉注射给药的AUC值计算得出的生物利用度——F%，范围为30%-34%。静脉注射后，泰乐菌素在体内迅速分布，消除半衰期（t1/2β）值为0.52小时，分布容积（Vd）为0.69L/kg，清除率（Cl）为5.30±0.59ml/min/kg。口服给药后，泰乐菌素的分布容积相似（Vd = 0.85L/kg），而消除半衰期t1/2β为2.07小时，是静脉注射给药后（Cl = 4.40±0.27ml/min/kg）的四倍。口服给药后泰乐菌素的tmax = 1.5小时表明，在肉鸡饮用水中使用这种抗生素是首选方法。然而，口服泰乐菌素后相对较低的Cmax = 1.2μg/ml表明，肉鸡中这种抗生素的给药剂量应高于其他产肉动物。
