Sprygin V G, Kushnerova N F, Gordeĭchuk T N, Fomenko S E
Department of Biochemical Technologies, Il'ichev Pacific Oceanological Institute, Far East Division, Russian Academy of Sciences, ul. Baltiiskaya 43, Vladivostok, 690041 Russia.
Eksp Klin Farmakol. 2002 Jul-Aug;65(4):56-8.
Diprim, a polyphenol preparation from crests of Far-Eastern grape species, influences the carbohydrate and lipid metabolism in liver of rats subjected to stress. The drug possesses antistress properties determined by the biologically active natural polyphenol derivatives. Playing the role of a buffer redox system under the stressed conditions, the polyphenol structures provide for the possibility of retaining the carbohydrate and lipid metabolism in rat liver and creating a reserve of the oxidized form of nicotinamide NAD+ coenzyme, which favors removal of the tissue hypoxia. The antioxidant properties of polyphenols from diprim preserve the phospholipid spectrum of the plasmic membranes of hepatocytes.
迪普林是一种从远东葡萄品种的葡萄梗中提取的多酚制剂，它会影响遭受应激的大鼠肝脏中的碳水化合物和脂质代谢。该药物具有由生物活性天然多酚衍生物所决定的抗应激特性。在应激条件下，多酚结构发挥缓冲氧化还原系统的作用，为维持大鼠肝脏中的碳水化合物和脂质代谢以及储备烟酰胺NAD+辅酶的氧化形式提供了可能性，这有利于消除组织缺氧。迪普林中多酚的抗氧化特性可维持肝细胞质膜的磷脂谱。
