[谷氨酸能药物的研究与临床应用的现代进展]

[Modern aspects of investigation and clinical application of glutamatergic agents].

作者信息

Petrov V I, Onishchenko N V

机构信息

Institute of Pharmacology, Volgograd State Medical Academy, Ministry of Public Health of the Russian Federation, pl. Pavshikh Bortsov 1, Volgograd, 400131 Russia.

出版信息

Eksp Klin Farmakol. 2002 Jul-Aug;65(4):66-70.

PMID:12449079

Abstract

The paper considers the main trends in development and summarizes the results of experimental and clinical investigations of glutamatergic drugs, including the glutamate synthesis and release inhibitors, NMDA receptor antagonists, AMPA receptor antagonists and positive modulants, and metabotropic glutamate receptors ligands.

摘要

本文探讨了其主要发展趋势，并总结了谷氨酸能药物的实验和临床研究结果，包括谷氨酸合成和释放抑制剂、NMDA受体拮抗剂、AMPA受体拮抗剂和正性调节剂，以及代谢型谷氨酸受体配体。