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[肝素对成年及幼年兔肌肉线粒体Mg++ - ATP酶的影响]

[Effect of heparin on the Mg++-ATPase of the muscle mitochondria of adult and young rabbits].

作者信息

Dubinina E E

出版信息

Vopr Med Khim. 1975 Mar-Apr;21(2):128-31.

PMID:124504
Abstract

ATPase activity from freshly prepared, "aged" and "heparin" mitochondria was studied in adult, newborn and 7 day old rabbits. Heparin, incubated with the mitochondria within 2-2.5 hrs at 20 degrees C, increased the activity of endogenous ATPase in the newborn rabbits. Activities of Mg-2++-ATPase and Mg-2+-DNP-ATPase were decreased under effect of heparin in both adult and new born rabbits. In 7 day old rabbits, to the contrary, increased activity of Mg-2+-ATPase and its activation by 2,4-DNP were observed.

摘要

在成年、新生和7日龄兔中研究了新鲜制备的、“老化”的和“肝素处理”的线粒体的ATP酶活性。肝素在20℃下与线粒体一起孵育2至2.5小时,可增加新生兔内源性ATP酶的活性。在成年兔和新生兔中,肝素作用下Mg²⁺ -ATP酶和Mg²⁺ -DNP-ATP酶的活性均降低。相反,在7日龄兔中,观察到Mg²⁺ -ATP酶的活性增加及其被2,4-二硝基苯酚激活。

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