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ETV6-NTRK3--Trk-ing the primary event in human secretory breast cancer.

作者信息

Euhus David M, Timmons Charles F, Tomlinson Gail E

机构信息

Department of Surgery, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

出版信息

Cancer Cell. 2002 Nov;2(5):347-8. doi: 10.1016/s1535-6108(02)00184-8.

DOI:10.1016/s1535-6108(02)00184-8
PMID:12450787
Abstract

In this issue of Cancer Cell, propose a single chromosomal translocation as the cause of a particularly troubling form of breast cancer, secretory carcinoma. They challenge widely held beliefs concerning breast carcinogenesis as well as beliefs concerning the absolute association of specific fusion genes with specific tumor types. Their data highlight the role of Trk signaling in breast cancer and also suggest a target for drug development.

摘要

相似文献

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ETV6-NTRK3--Trk-ing the primary event in human secretory breast cancer.
Cancer Cell. 2002 Nov;2(5):347-8. doi: 10.1016/s1535-6108(02)00184-8.
2
Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma.ETV6-NTRK3基因融合作为人类分泌性乳腺癌的原发性事件的表达。
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Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity.ETV6-NTRK3嵌合酪氨酸激酶的SAM结构域中的突变会阻断聚合和转化活性。
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The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells.ETV6-NTRK3基因融合编码一种嵌合蛋白酪氨酸激酶，可转化NIH3T3细胞。
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Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors.ETV6-NTRK3基因融合的分子检测可将先天性纤维肉瘤与其他儿童期梭形细胞肿瘤区分开来。
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Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues.先天性婴儿纤维肉瘤：10例临床病理研究及应用石蜡包埋组织对ETV6-NTRK3融合转录本进行分子检测
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The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation.嵌合蛋白酪氨酸激酶ETV6-NTRK3在成纤维细胞转化过程中需要Ras-Erk1/2和PI3激酶-Akt信号通路的共同作用。
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