估算镰状细胞贫血青少年静息能量消耗的方程式。

Equation to estimate resting energy expenditure in adolescents with sickle cell anemia.

作者信息

Buchowski Maciej S, Chen Kong Y, Byrne Daniel, Wang Winfred C

机构信息

Center for Nutrition and Department of Family and Community Medicine, Meharry Medical College, Nashville, TN 37208, USA.

出版信息

Am J Clin Nutr. 2002 Dec;76(6):1335-44. doi: 10.1093/ajcn/76.6.1335.

DOI:10.1093/ajcn/76.6.1335

PMID:12450901

Abstract

BACKGROUND

Basal energy requirements are higher in adolescents with sickle cell anemia (SCA) than in healthy control subjects. However, no equation is available to accurately predict their energy needs.

OBJECTIVE

Our objective was to develop a clinically useful equation to estimate resting energy expenditure (REE) in adolescents with SCA.

DESIGN

REE and other components of total energy expenditure were measured in adolescents with SCA (n = 37) and in control subjects (n = 23) for 24 h in a whole-room indirect calorimeter. Multiple linear regression analysis was used to describe the relations of REE with independent variables such as sex, weight, height, fat-free mass, fat mass, age, and hemoglobin concentration in adolescents with SCA. The Bland-Altman comparison technique was used to compare values predicted by existing equations with measured REE values.

RESULTS

Mean (+/-SD) measured REEs were 7746 +/- 974 and 6332 +/- 869 kJ/d in the male and female subjects with SCA, respectively, and these values were 16% higher than those in the healthy control subjects. Standard equations underestimated REE by 12% (P </= 0.001) in adolescents with SCA and overestimated REE by 4% in control subjects (P = 0.01-0.29). Several REE regression equations for SCA were developed. The most parsimonious equation for males was REE (kJ/d) = 5461 + 77.7.weight (kg) - 233.2.hemoglobin (g/dL), or REE (kcal/d) = 1305 + 18.6.weight (kg) - 55.7.hemoglobin (g/dL). For females, the most parsimonious equation was REE (kJ/d) = 4603 + 55.6.weight (kg) - 126.2.hemoglobin (g/dL), or REE (kcal/d) = 1100 + 13.3.weight (kg) - 30.2.hemoglobin (g/dL).

CONCLUSION

The new equations have better agreement with the basal metabolic needs of adolescents with SCA than do standard predictive equations.

摘要

背景

镰状细胞贫血（SCA）青少年的基础能量需求高于健康对照者。然而，尚无能够准确预测其能量需求的公式。

目的

我们的目的是制定一个临床实用公式，以估算SCA青少年的静息能量消耗（REE）。

设计

在全室间接热量计中对37名SCA青少年和23名对照者进行24小时的REE及总能量消耗的其他组成部分的测量。采用多元线性回归分析来描述SCA青少年中REE与性别、体重、身高、去脂体重、脂肪量、年龄及血红蛋白浓度等自变量之间的关系。采用Bland-Altman比较技术，将现有公式预测值与测量的REE值进行比较。

结果

SCA男性和女性受试者测量的平均（±标准差）REE分别为7746±974和6332±869kJ/d，这些值比健康对照者高16%。标准公式在SCA青少年中低估REE 12%（P≤0.001），在对照者中高估REE 4%（P=0.01-0.29）。制定了几个SCA的REE回归公式。男性最简洁的公式为REE（kJ/d）=5461+77.7×体重（kg）-233.2×血红蛋白（g/dL），或REE（kcal/d）=1305+18.6×体重（kg）-55.7×血红蛋白（g/dL）。对于女性，最简洁的公式为REE（kJ/d）=4603+55.6×体重（kg）-126.2×血红蛋白（g/dL），或REE（kcal/d）=1100+13.3×体重（kg）-30.2×血红蛋白（g/dL）。