Forrester Janet E, Spiegelman Donna, Tchetgen Eric, Knox Tamsin A, Gorbach Sherwood L
Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, MA 02111, USA.
Am J Clin Nutr. 2002 Dec;76(6):1428-34. doi: 10.1093/ajcn/76.6.1428.
The nature of body-composition changes in HIV-associated weight loss is unclear.
We examined the relation between the initial percentage of body fat and the composition of weight loss in men and women with HIV infection.
HIV-positive adults were seen at semiannual clinic visits, at which time weight, fat, and fat-free mass were determined. The unit of analysis was the person-interval.
Five hundred fifty-one persons contributed 2266 intervals of data, of which 311 (14%) were intervals in which weight loss was >/= 5% of initial (start of interval) weight. Of these, 208 (67%) intervals met the criteria for analysis (123 from men and 85 from women). Loss of fat-free mass was dependent on the initial percentage of body fat in the men with < 32% body fat. A plot of the initial percentage of body fat compared with loss of fat-free mass (kg) suggested a nonlinear relation over the range of body fat examined. There was no clear relation between the initial percentage of body fat and loss of fat-free mass in the women.
In men with HIV-associated weight loss, the weight lost as fat-free mass depends on the initial percentage of body fat at low levels of body fat but appears to be independent of initial percentage of body fat at high levels of body fat. In women with HIV-associated weight loss who have normal-to-high body fat stores, loss of fat-free mass is independent of the initial percentage of body fat.
HIV相关体重减轻中身体成分变化的本质尚不清楚。
我们研究了HIV感染男性和女性的初始体脂百分比与体重减轻组成之间的关系。
HIV阳性成年人每半年到诊所就诊一次，届时测定体重、脂肪和去脂体重。分析单位为人-时间间隔。
551人提供了2266个时间间隔的数据，其中311个（14%）时间间隔体重减轻≥初始（时间间隔开始时）体重的5%。其中，208个（67%）时间间隔符合分析标准（男性123个，女性85个）。体脂百分比<32%的男性去脂体重的减少取决于初始体脂百分比。将初始体脂百分比与去脂体重减少量（kg）作图，显示在所研究的体脂范围内呈非线性关系。女性的初始体脂百分比与去脂体重减少之间没有明确关系。
在HIV相关体重减轻的男性中，以去脂体重形式减轻的体重在低体脂水平时取决于初始体脂百分比，但在高体脂水平时似乎与初始体脂百分比无关。在体脂储存正常至高的HIV相关体重减轻的女性中，去脂体重的减少与初始体脂百分比无关。
