Kolenda K D
Dtsch Med Wochenschr. 1976 Jan 16;101(3):84-6. doi: 10.1055/s-0028-1104039.
Marked, and in some cases long-lasting, taste disturbances occurred in three patients on thiamazole. In addition, all three had a rise in serum transaminases and alkaline phosphatase levels, due to associated liver parenchymal damage. Cause of these changes was the high thiamazole dosage (160 and 120 mg/d). Reduction in dosage restored normal taste sense in all three, but in two the drug had to be discontinued because of persisting high transaminase levels.
三名服用甲巯咪唑的患者出现了明显的味觉障碍，在某些情况下这种味觉障碍持续时间较长。此外，由于伴有肝实质损伤，这三名患者的血清转氨酶和碱性磷酸酶水平均有所升高。这些变化的原因是甲巯咪唑剂量过高（160毫克/天和120毫克/天）。减少剂量后，三名患者的味觉均恢复正常，但有两名患者因转氨酶水平持续升高而不得不停药。
