Bomhard D V, Raddatz R
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975;83(2):129-43.
The electronmicroscopic findings of nine solid mammary carcinomas in bitches are described as well as the observations on tumour cells within lymphatic vessels. In the primary tumours basement membranes surround the cords of tumour cell. In five cases, particularly in two, there are cells with long intracytoplasmic filaments measuring about 65 A thick. The filaments are arranged along the axis of the cells and show focal densities. These cells are presumed to be myoepithelial tumour cells. In eight of the nine tumours there are also carcinoma cells with short single or bundled intracytoplasmic filaments of approximately the same thickness (65 A). These however show no specific order, they are perinuclear or lie in between the organelles. They are called tonofibrillae. Viruses or virus-like particles have not been found.
描述了9例母犬实体性乳腺癌的电子显微镜检查结果以及对淋巴管内肿瘤细胞的观察。在原发性肿瘤中,基底膜围绕肿瘤细胞索。在5例中,特别是2例中,存在具有长约65埃厚的胞质内细丝的细胞。细丝沿细胞轴排列并显示局灶性致密区。这些细胞被推测为肌上皮肿瘤细胞。在9个肿瘤中的8个中,也存在具有短的单根或成束的胞质内细丝的癌细胞,其厚度大致相同(65埃)。然而,这些细丝没有特定的排列顺序,它们位于核周或细胞器之间。它们被称为张力原纤维。未发现病毒或病毒样颗粒。