Schwan H P, McAdams E T, Jossinet J
Bioengineering Department, University of Pennsylvania, Philadelphia, USA.
Med Biol Eng Comput. 2002 Sep;40(5):542-5. doi: 10.1007/BF02345452.
The non-linearity of the electrode-tissue interface impedance gives rise to harmonics and thus degrades the accuracy of impedance measurements. Also, electrodes are often driven into the non-linear range of their polarisation impedance. This is particularly true in clinical applications. Techniques to correct for electrode effects are usually based on linear electrode impedance data. However, these data can be very different from the non-linear values needed. Non-linear electrode data suggested a model based on simple assumptions. It is useful in predicting the frequency dependence of non-linear effects from linear properties. Sauer's treatment is a first attempt to provide a more general and rigorous basis for modelling the non-linear state. The paper reports Sauer's treatment of the non-linear case and points out its limitations. The paper considers Sauer's treatment of a series arrangement of two impedances. The tissue impedance is represented by a linear voltage-current characteristic. The interface impedance is represented by a Volterra expansion. The response of this network to periodic signals is calculated up to the second-order term of the series expansion. The resultant, time-dependent current is found to contain a DC term (rectification), as well as frequency-dependent terms. Sauer's treatment assumes a voltage clamp across the impedances and neglects higher-order terms in the series expansion. As a consequence, it fails adequately to represent some experimentally observed phenomena. It is therefore suggested that Sauer's expressions for the voltage divider should be combined with the non-linear treatments previously published by the co-authors. Although Sauer's work on the non-linear voltage divider was originally applied to the study of the non-linear behaviour of the electrode-electrolyte interface and biological tissues, it is stressed, however, that the work is applicable to a wide range of research areas.
电极 - 组织界面阻抗的非线性会产生谐波,从而降低阻抗测量的准确性。此外,电极常常会被驱动到其极化阻抗的非线性范围内。在临床应用中尤其如此。校正电极效应的技术通常基于线性电极阻抗数据。然而,这些数据可能与所需的非线性值有很大差异。非线性电极数据提出了一个基于简单假设的模型。它有助于从线性特性预测非线性效应的频率依赖性。绍尔的处理方法是为非线性状态建模提供更通用和严格基础的首次尝试。本文报道了绍尔对非线性情况的处理方法,并指出了其局限性。本文考虑了绍尔对两个阻抗串联排列的处理。组织阻抗由线性电压 - 电流特性表示。界面阻抗由沃尔泰拉展开式表示。计算该网络对周期信号的响应,直至级数展开的二阶项。结果发现,随时间变化的电流包含一个直流项(整流)以及与频率相关的项。绍尔的处理方法假设跨阻抗的电压钳位,并忽略级数展开中的高阶项。因此,它未能充分表示一些实验观察到的现象。因此建议将绍尔的分压器表达式与共同作者先前发表的非线性处理方法相结合。尽管绍尔关于非线性分压器的工作最初应用于研究电极 - 电解质界面和生物组织的非线性行为,但需要强调的是,这项工作适用于广泛的研究领域。