Camarda Rosolino, Monastero Roberto, Santangelo Giuseppe, Raimondo Domenico, Puma Domenico, Pipia Carmela, Camarda Lawrence K C, Camarda Cecilia, Raieli Vincenzo
Department of Neurology and Rehabilitation, Institute of Neuropsychiatry, University of Palermo, Italy.
Headache. 2002 Nov-Dec;42(10):1000-5. doi: 10.1046/j.1526-4610.2002.02229.x.
Longitudinal studies of juvenile migraine are very few. We investigated the prevalence and evolution over 5 years of migraine without aura (MWOA) and migraineous disorder (MD) in an adolescent population.
Sixty-four subjects (34 girls and 30 boys, mean age 17.3+/-1.1 years) out of 80 selected in our 1989 epidemiological survey were included in the study. The diagnostic criteria of the International Headache Society were used in both studies.
Thirty-two of 64 subjects (50%) had MWAO, 18 (28.1%) had MD, and 14 (21.9%) had headache not classifiable (HnC). Our results show that MWOA persisted in 56.2%, converted to MD or HnC in 9.4% and 3.1% of cases, respectively, changed to episodic tension-type headache (ETTH) in 12.5%, and remitted in 18.8%. MD persisted in 11.1%, converted to MWOA or HnC in 27.8% and 5.5% of cases, respectively, changed to ETTH in 11.1%, and remitted in 44.5%. HnC persisted in 14.3%, converted to MD or MWOA in 21.4% and 14.3% of cases, respectively, changed to ETTH in 14.3%, and remitted in 35.7%.
Our data indicate that juvenile-onset MWOA and MD may change in character over time, generally with a favorable prognosis.
关于青少年偏头痛的纵向研究非常少。我们调查了青少年人群中无先兆偏头痛（MWOA）和偏头痛性疾病（MD）在5年期间的患病率及演变情况。
在我们1989年流行病学调查中选取的80名受试者中，有64名（34名女孩和30名男孩，平均年龄17.3±1.1岁）被纳入研究。两项研究均采用国际头痛协会的诊断标准。
64名受试者中，32名（50%）患有MWOA，18名（28.1%）患有MD，14名（21.9%）患有无法分类的头痛（HnC）。我们的研究结果显示，MWOA持续存在的病例占56.2%，分别有9.4%和3.1%的病例转变为MD或HnC，12.5%的病例转变为发作性紧张型头痛（ETTH），18.8%的病例缓解。MD持续存在的病例占11.1%，分别有27.8%和5.5%的病例转变为MWOA或HnC，11.1%的病例转变为ETTH，44.5%的病例缓解。HnC持续存在的病例占14.3%，分别有21.4%和14.3%的病例转变为MD或MWOA，14.3%的病例转变为ETTH，35.7%的病例缓解。
我们的数据表明，青少年期起病的MWOA和MD可能会随时间改变特征，总体预后良好。
