Langham M E, Krieglstein G K
Invest Ophthalmol. 1976 Feb;15(2):119-27.
A study has been made of the pupillary and intraocular pressure responses of conscious rabbits to daily topical applications of submaximal doses of epinephrine. On the first day, epinephrine caused rapid pupil dilation which preceded a prolonged -ecrease of intraocular pressure. On the second and subsequent days, the application of the same dose of epinephrine increased the duration of the pupillary response and caused a biphasic pressure response in all treated eyes; an initial increase of intraocular pressure lasting two to four hours followed by decrease of intraocular pressure below the initial value which lasted for more than twenty-four hours. The beta-receptor antagonist, propranolol, and the alpha-receptor antagonist, phenoxybenzamine, caused small and large reductions, respectively, in the hypertensive response to epinephrine. Phenoxybenzamine, but not propranolol, also inhibited the pupil dilation and the hypotensive response to epinephrine. Topical administration of phenoxybenzamine strongly inhibited the hypertensive response to epinephrine but left unaffected the pupillary response.
一项关于清醒家兔对每日局部应用次最大剂量肾上腺素的瞳孔和眼压反应的研究已经开展。第一天，肾上腺素引起快速的瞳孔扩张，随后眼压出现长时间下降。在第二天及之后的日子里，应用相同剂量的肾上腺素增加了瞳孔反应的持续时间，并在所有受试眼中引起双相压力反应；眼压最初升高持续两到四个小时，随后眼压下降至初始值以下并持续超过二十四小时。β受体拮抗剂普萘洛尔和α受体拮抗剂酚苄明分别使对肾上腺素的高血压反应有小幅和大幅降低。酚苄明而非普萘洛尔也抑制了对肾上腺素的瞳孔扩张和降压反应。局部应用酚苄明强烈抑制了对肾上腺素的高血压反应，但对瞳孔反应没有影响。
