Hoyng P F, de Jong N
Invest Ophthalmol Vis Sci. 1987 Mar;28(3):470-6.
Topical application of Iloprost caused a dose-dependent decrease in intraocular pressure (IOP) in rabbits and ocular hypertensive beagles. In rabbits, the IOP response was biphasic and miosis was observed. In beagles, there was no initial hypertensive phase, and the fall in IOP was more pronounced (up to 37%). In beagles, Iloprost did not influence pupillary diameter. A mild transient hyperemia was noted in both rabbit and beagle eyes. Iloprost led to an increase in the aqueous humor protein concentration in rabbits but not in beagles. The use of artificial tears as vehicle enhanced the effect on intraocular pressure but also aqueous protein in rabbits. The central corneal temperature was increased after application of Iloprost in both rabbits and beagles. In rabbits, tonography revealed an increase in outflow facility during both the hypertensive and the hypotensive phases. Iloprost caused a decrease in mean arterial pressure in beagles; the effect on pulse rate was inconsequential. It is suggested that similar low doses of an analog of Iloprost or carboprostacyclin that does not affect the hemodynamic equilibrium could be of value in the treatment of glaucoma.
伊洛前列素局部应用可使兔和高眼压比格犬的眼压呈剂量依赖性降低。在兔中，眼压反应呈双相性，且观察到瞳孔缩小。在比格犬中，无初始高血压期，眼压下降更为明显（高达37%）。在比格犬中，伊洛前列素不影响瞳孔直径。兔和比格犬的眼睛均出现轻度短暂性充血。伊洛前列素可使兔房水蛋白浓度升高，但对比格犬无此作用。使用人工泪液作为载体可增强对眼压的作用，但也会增加兔房水蛋白含量。在兔和比格犬中应用伊洛前列素后，中央角膜温度均升高。在兔中，眼压描记显示在高血压期和低血压期房水流畅系数均增加。伊洛前列素可使比格犬平均动脉压降低；对脉搏率的影响不显著。有人提出，类似低剂量的不影响血液动力学平衡的伊洛前列素或卡前列环素类似物可能对青光眼治疗有价值。
