三个冗余的油菜素内酯早期反应基因编码正常生长所需的假定bHLH转录因子。
Three redundant brassinosteroid early response genes encode putative bHLH transcription factors required for normal growth.
作者信息
Friedrichsen Danielle M, Nemhauser Jennifer, Muramitsu Takamichi, Maloof Julin N, Alonso José, Ecker Joseph R, Furuya Masaki, Chory Joanne
机构信息
Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
出版信息
Genetics. 2002 Nov;162(3):1445-56. doi: 10.1093/genetics/162.3.1445.
Abstract
Brassinosteroids (BRs) are a class of polyhydroxylated steroids that are important regulators of plant growth and development. We have identified three closely related basic helix-loop-helix (bHLH) transcription factors, BEE1, BEE2, and BEE3, as products of early response genes required for full BR response. Comparison of the phenotypes of plants that overexpress BEE1 with bee1 bee2 bee3 triple-knockout mutant plants suggests that BEE1, BEE2, and BEE3 are functionally redundant positive regulators of BR signaling. Expression of BEE1, BEE2, and BEE3 is also regulated by other hormones, notably abscisic acid (ABA), a known antagonist of BR signaling. Reduced ABA response in plants overexpressing BEE1 suggests that BEE proteins may function as signaling intermediates in multiple pathways.
摘要
油菜素甾醇（BRs）是一类多羟基类固醇，是植物生长和发育的重要调节剂。我们已经鉴定出三个密切相关的碱性螺旋-环-螺旋（bHLH）转录因子BEE1、BEE2和BEE3，它们是BR完全应答所需的早期反应基因的产物。过表达BEE1的植物与bee1 bee2 bee3三敲除突变体植物的表型比较表明，BEE1、BEE2和BEE3是BR信号传导功能冗余的正调节因子。BEE1、BEE2和BEE3的表达也受其他激素调节，尤其是脱落酸（ABA），它是已知的BR信号传导拮抗剂。过表达BEE1的植物中ABA反应降低，这表明BEE蛋白可能作为多种途径中的信号中间体发挥作用。
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本文引用的文献
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BAK1, an Arabidopsis LRR receptor-like protein kinase, interacts with BRI1 and modulates brassinosteroid signaling.BAK1是一种拟南芥LRR类受体蛋白激酶，它与BRI1相互作用并调节油菜素内酯信号传导。
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The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis.类糖原合成酶激酶3（GSK3）的BIN2激酶使拟南芥油菜素类固醇信号通路的正向调节因子BZR1磷酸化并使其不稳定。
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BRS1, a serine carboxypeptidase, regulates BRI1 signaling in Arabidopsis thaliana.BRS1是一种丝氨酸羧肽酶，可调节拟南芥中的BRI1信号传导。
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