Brodland G Wayne
Department of Civil Engineering, University of Waterloo, Waterloo, ON, Canada N2L 3G1.
Biorheology. 2003;40(1-3):273-7.
In order to verify theories about the mechanics of cell sorting, tissue spreading and checkerboard pattern formation, it is necessary to measure certain cell properties such as surface tension and adhesiveness. The purpose of this work is to clarify the relationship between these two important properties and to use computer simulations and analytical calculations to extract additional information from parallel plate compression tests. This paper shows that compression tests can be used to determine not only the surface tension between the aggregate and the surrounding medium, but also the effective viscosity of the cell cytoplasm and the interfacial tension that acts between the cells that make up the aggregate. The findings reported here also support a novel, differential interfacial tension-based theory for cell sorting, tissue spreading and checkerboard pattern formation, and pose further challenges to current differential adhesion-based models.
为了验证关于细胞分选、组织铺展和棋盘格图案形成机制的理论，有必要测量某些细胞特性，如表面张力和粘附性。这项工作的目的是阐明这两个重要特性之间的关系，并使用计算机模拟和分析计算从平行板压缩试验中提取更多信息。本文表明，压缩试验不仅可用于确定聚集体与周围介质之间的表面张力，还可用于确定细胞质的有效粘度以及构成聚集体的细胞之间作用的界面张力。本文报道的研究结果还支持一种基于新型差异界面张力的细胞分选、组织铺展和棋盘格图案形成理论，并对当前基于差异粘附的模型提出了进一步挑战。
