Blondel Walter C P M, Lehalle Bertrand, Lercher Marie-Noëlle, Dumas Dominique, Bensoussan Danielle, Stoltz Jean-François
Cell and Tissue Mechanics and Engineering Laboratory (LEMTA), UMR CNRS 7563 and IFR Bio-Engineering, Faculty of medicine, 54500 Vandoeuvre-lès-Nancy, France.
Biorheology. 2003;40(1-3):369-76.
The aim of this study was to determine the comparative three-dimensional mechanical properties of healthy and atherosclerotic muscular human arteries. Using a previously developed experimental system, in vitro inflation tests were performed on twelve segments of arteries, in static conditions. Two different initial states were used to carry the mechanical study through (large deformation, thick-walled). Main significant differences between healthy and atherosclerotic tested segments are observed for axial traction force whatever the initial state and radial and circumferencial strains referenced to longitudinally pre-stretched state. We showed that strain energy allows to differentiate between both types of arteries only when absolute values of transversal components were considered. Differential values of energy were not discriminating. Our results also show the potential interest of studying arteries in vivo at low transmural pressure.
本研究的目的是确定健康和动脉粥样硬化的人体肌肉动脉的三维力学性能比较。使用先前开发的实验系统，在静态条件下对12个动脉段进行体外充气试验。通过两种不同的初始状态进行力学研究（大变形、厚壁）。无论初始状态如何，对于轴向牵引力以及相对于纵向预拉伸状态的径向和周向应变，在健康和动脉粥样硬化测试段之间观察到主要的显著差异。我们表明，只有当考虑横向分量的绝对值时，应变能才能区分两种类型的动脉。能量的差值没有鉴别作用。我们的结果还表明了在低跨壁压力下对体内动脉进行研究的潜在意义。
