A simple and sensitive gas chromatographic method for the determination of clonazepam in human plasma.
作者信息
Gerna M, Morselli P L
出版信息
J Chromatogr. 1976 Jan 21;116(2):445-50. doi: 10.1016/s0021-9673(00)89915-x.
PMID:1245581
Abstract
A simple gas chromatographic method for the determination of clonazepam in human plasma has been developed. After solvent extraction, the compound is measured by an electron capture detector on an OV-17 column. The electron-capture response is linear for 5-120 ng/ml of plasma. There is no interference from other commonly used anti-epileptic drugs or endogenous substrates. Preliminary data from routin monitoring of epileptic patients shows a 10-fold variation in their clonazepam plasma levels.
摘要
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