Bamberger E S, Perrett C W
Department of Biology, University of Haifa at Oranim, Tivon 36006, Israel.
Mol Pathol. 2002 Dec;55(6):348-59. doi: 10.1136/mp.55.6.348.
Angiogenesis, the development of new blood vessels from the existing vasculature, is an essential component of solid tumour growth and metastasis. Several angiogenic factors are expressed by many tumours, suggesting that tumours promote their own vascularisation by activating the host endothelium. This review will discuss various angiogenic stimulators and inhibitors in epithelian ovarian cancer (EOC), including vascular endothelial growth factor and platelet derived endothelial cell growth factor/thymidine phosphorylase. The analysis of tumour vascularisation by microvessel density will also be discussed and the relevance of these markers of angiogenesis in the prognosis of EOC will be assessed.
血管生成,即从现有脉管系统发育出新的血管,是实体瘤生长和转移的重要组成部分。许多肿瘤都会表达多种血管生成因子,这表明肿瘤通过激活宿主内皮细胞来促进自身血管化。本综述将讨论上皮性卵巢癌(EOC)中的各种血管生成刺激因子和抑制因子,包括血管内皮生长因子和血小板衍生内皮细胞生长因子/胸苷磷酸化酶。还将讨论通过微血管密度分析肿瘤血管生成的情况,并评估这些血管生成标志物在EOC预后中的相关性。