Wang S, Xia T, Zhang Z, Kong X, Zeng L, Mi P, Xue Z
Institute of Urology, Beijing Medical University, Beijing 100034, China.
Zhonghua Wai Ke Za Zhi. 2000 Jan;38(1):34-6.
To evaluate expression of vascular endothelial growth factor (VEGF) and its relation to angiogenesis in bladder cancer.
The expression of VEGF by immunohistochemical staining was examined in 68 cases of primary transitional carcinoma (TCC) and 7 subjects with normal urothelium. Microvessel density (MVD) in 40 cases of invasive bladder cancer was determined by Factor VIII immunohistochemical staining.
The expression of VEGF was negative or low level in all normal bladder tissue but high in bladder cancer. VEGF and MVD were closely related to tumor cell nuclear grade and clinical stage. The average MVD was higher in the cases with the high level expression of VEGF, than in those with the low level expression of VEGF.
This study indicates that VEGF is positively correlated with the occurrence and progression of bladder cancer. VEGF is one of the primary angiogenic factors for bladder cancer, and is able to induce tumor angiogenesis and accelerate tumor growth. Quantification of VEGF may provide a valuable marker for a poorer prognosis of patients.
评估血管内皮生长因子（VEGF）的表达及其与膀胱癌血管生成的关系。
采用免疫组织化学染色法检测68例原发性移行细胞癌（TCC）和7例正常尿路上皮组织中VEGF的表达。应用因子VIII免疫组织化学染色法测定40例浸润性膀胱癌的微血管密度（MVD）。
所有正常膀胱组织中VEGF表达为阴性或低水平，而在膀胱癌中VEGF表达较高。VEGF和MVD与肿瘤细胞核分级及临床分期密切相关。VEGF高表达病例的平均MVD高于VEGF低表达病例。
本研究表明VEGF与膀胱癌的发生和进展呈正相关。VEGF是膀胱癌主要的血管生成因子之一，能够诱导肿瘤血管生成并加速肿瘤生长。VEGF定量检测可为患者预后较差提供有价值的标志物。
