人类肿瘤相关抗原RCAS1的过表达与甲状腺癌的去分化显著相关。

Overexpression of human tumor-associated antigen, RCAS1, is significantly linked to dedifferentiation of thyroid carcinoma.

作者信息

Ito Yasuhiro, Yoshida Hiroshi, Nakano Keiichi, Kobayashi Kaoru, Yokozawa Tamotsu, Hirai Keisuke, Matsuzuka Fumio, Matsuura Nariaki, Kuma Kanji, Miyauchi Akira

机构信息

Kuma Hospital, Kobe, Japan.

出版信息

Oncology. 2003;64(1):83-9. doi: 10.1159/000066517.

DOI:10.1159/000066517

PMID:12457035

Abstract

OBJECTIVE

Counterattack by RCAS1 on carcinoma to cytotoxic T cells and natural killer (NK) cells has been suggested as a contribution to carcinoma progression, because RCAS1 can inhibit their proliferation and induce apoptosis. In this study, we examined RCAS1 expression in various thyroid neoplasms in order to clarify its clinical significance.

METHODS

We studied RCAS1 expression by means of immunohistochemistry using a mouse monoclonal antibody against RCAS1 for normal thyroid epithelium, follicular adenoma, follicular carcinoma, papillary carcinoma and undifferentiated (anaplastic) carcinoma.

RESULTS

Normal epithelium and follicular adenoma did not express or only faintly expressed RCAS1. In thyroid carcinomas. RCAS1 overexpression was more frequently observed in anaplastic (undifferentiated) carcinomas than papillary (p < 0.0001) and follicular carcinomas (p = 0.0018). In follicular carcinoma, the widely invasive type more frequently overexpressed RCAS1 than the minimally invasive type (p = 0.0488). Furthermore, the incidences of RCAS1 overexpression increased with carcinoma dedifferentiation (p < 0.0001).

CONCLUSION

These results suggest that RCAS1 may contribute to the progression of thyroid carcinoma with high biological aggressiveness.

摘要

目的

已有研究表明，RCAS1对细胞毒性T细胞和自然杀伤（NK）细胞的反击作用有助于癌症进展，因为RCAS1可抑制它们的增殖并诱导细胞凋亡。在本研究中，我们检测了RCAS1在各种甲状腺肿瘤中的表达，以阐明其临床意义。

方法

我们使用抗RCAS1的小鼠单克隆抗体，通过免疫组织化学方法研究了正常甲状腺上皮、滤泡性腺瘤、滤泡性癌、乳头状癌和未分化（间变性）癌中RCAS1的表达。

结果

正常上皮和滤泡性腺瘤不表达或仅微弱表达RCAS1。在甲状腺癌中，间变性（未分化）癌比乳头状癌（p < 0.0001）和滤泡性癌（p = 0.0018）更常观察到RCAS1过表达。在滤泡性癌中，广泛浸润型比微浸润型更常过表达RCAS1（p = 0.0488）。此外，RCAS1过表达的发生率随癌的去分化而增加（p < 0.0001）。