Department of Pathology, Head and Neck Surgery, Institute Curie, Paris, France.
Med Sci Monit. 2011 Aug;17(8):BR228-234. doi: 10.12659/msm.881902.
The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance. The present study aimed to evaluate the clinical significance of RCAS1 expression in mobile tongue squamous cell carcinoma (SCC).
MATERIAL/METHODS: RCAS1 protein expression was assessed immunohistochemically on 49 mobile tongue SCC tissue samples obtained from an equal number of patients and was statistically analyzed with clinicopathological characteristics and overall and disease-free patients' survival.
Enhanced RCAS1 expression was significantly associated with reduced depth of invasion (p=0.0069), low mitotic index (p=0.0251) and no evidence of muscular invasion (p=0.0098). A borderline association between RCAS1 expression and stromal inflammatory reaction was also noted (p=0.0660). RCAS1 expression was not associated with overall and disease-free survival.
Our data support evidence for possible implication of RCAS1 at the early stage of tumor progression in mobile tongue SCC, whereas the survival prediction using RCAS1 expression as a clinical marker seems uncertain for this type of malignancy.
SiSo 细胞上表达的受体结合癌抗原（RCAS1）是人肿瘤相关抗原，它被认为通过使癌细胞逃避免疫监视在肿瘤进展中发挥关键作用。本研究旨在评估 RCAS1 表达在移动性舌鳞癌（SCC）中的临床意义。
材料/方法：对 49 例移动性舌 SCC 组织标本进行免疫组化评估 RCAS1 蛋白表达，并对其与临床病理特征以及总生存率和无病生存率进行统计学分析。
增强的 RCAS1 表达与浸润深度降低显著相关（p=0.0069），与有丝分裂指数低（p=0.0251）和无肌肉侵犯相关（p=0.0098）。RCAS1 表达与间质炎症反应之间也存在边缘相关性（p=0.0660）。RCAS1 表达与总生存率和无病生存率无关。
我们的数据支持 RCAS1 在移动性舌 SCC 肿瘤进展早期可能具有一定意义的证据，而将 RCAS1 表达作为临床标志物用于预测生存似乎对这种类型的恶性肿瘤不确定。
