Martínez-Salas Encarnación, López de Quinto Sonia, Ramos Ricardo, Fernández-Miragall Olga
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Cantoblanco 28049, Madrid, Spain.
Biochimie. 2002 Aug;84(8):755-63. doi: 10.1016/s0300-9084(02)01408-6.
The activity of internal ribosome entry site (IRES) elements depends on their structural organization. We have addressed here the study of conserved structural motifs in the foot-and-mouth disease virus (FMDV) IRES as an example to understand the relationship between RNA structure and function. The features of the RNA structure known to be functionally relevant are discussed in regards to the capacity to modulate interaction of translation initiation factors with the FMDV IRES element. Additionally, the contribution of non-canonical RNA-binding proteins to FMDV IRES organization as well as stimulation of its activity by other mRNA regions is discussed.
内部核糖体进入位点（IRES）元件的活性取决于其结构组织。我们在此以口蹄疫病毒（FMDV）IRES中保守结构基序的研究为例，以了解RNA结构与功能之间的关系。就调节翻译起始因子与FMDV IRES元件相互作用的能力而言，讨论了已知具有功能相关性的RNA结构特征。此外，还讨论了非经典RNA结合蛋白对FMDV IRES组织的贡献以及其他mRNA区域对其活性的刺激作用。
