Inazumi Kosuke, Takahashi Daisuke, Taniguchi Toru, Yamamoto Tetsuya
Department of Ophthalmology, Gifu University School of Medicine, Japan.
Jpn J Ophthalmol. 2002 Sep-Oct;46(5):502-9. doi: 10.1016/s0021-5155(02)00540-3.
Exfoliation changes in the zonules or ciliary processes may be the earliest clinical sign of the exfoliation syndrome (XFS). In the present study we investigated the usefulness of ultrasound biomicroscopy (UBM) for detecting the early changes of XFS in zonules.
Both eyes of 11 patients with unilateral XFS and the unilateral eyes of 11 subjects without evidence of XFS were examined using UBM. The incidence of zonular changes was compared among the XFS-positive eyes of the patients, their contralateral XFS-negative eyes, and the healthy eyes of the subjects without XFS.
Using UBM, we could successfully describe the zonules in all UBM images of all subjects. In the four quadrants, the incidence of granular-type zonules was statistically different among the three groups: it was higher in XFP-positive eyes than in XFS-negative eyes, and it was higher in XFS-negative eyes than in healthy eyes.
UBM can detect the zonular changes that may occur early in XFS. A granular-type change in the zonules may be the most typical finding in the presence of exfoliation material. Diagnostic criteria are proposed for the early detection of XFS, based on the changes found in the zonules by UBM.
小带或睫状体的剥脱性改变可能是剥脱综合征（XFS）最早的临床体征。在本研究中，我们调查了超声生物显微镜（UBM）检测小带中XFS早期改变的实用性。
对11名单侧XFS患者的双眼以及11名无XFS证据受试者的单侧眼进行UBM检查。比较患者XFS阳性眼、对侧XFS阴性眼以及无XFS受试者的健康眼中小带改变的发生率。
使用UBM，我们能够成功描述所有受试者所有UBM图像中的小带。在四个象限中，三组之间颗粒状小带的发生率有统计学差异：XFS阳性眼中的发生率高于XFS阴性眼，XFS阴性眼中的发生率高于健康眼。
UBM能够检测到XFS早期可能出现的小带改变。小带的颗粒状改变可能是存在剥脱物质时最典型的表现。基于UBM在小带中发现的改变，提出了XFS早期检测的诊断标准。
