Lutterotti Andreas, Reindl Markus, Gassner Christoph, Poustka Katharina, Schanda Kathrin, Deisenhammer Florian, Berger Thomas
Department of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.
J Neuroimmunol. 2002 Oct;131(1-2):201-7. doi: 10.1016/s0165-5728(02)00271-0.
We investigated the association of the antibody response to myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) with human leukocyte antigen (HLA) class II alleles in 41 patients with sporadic multiple sclerosis (MS) and 12 multiplex MS families. We found significantly increased antibody response to MOG and MBP in MS patients without any difference to asymptomatic relatives. HLA DRB104 was associated with IgM reactivity to MOG in MS patients, and DRB115 and DRB5 with anti-MOG IgA among asymptomatic relatives. We conclude that antibody responses to MOG and MBP depend on familial background. Moreover, the humoral immune reactivity against MOG is partially under control of certain HLA class II alleles.
我们在41例散发型多发性硬化症（MS）患者和12个多发性MS家系中，研究了针对髓鞘少突胶质细胞糖蛋白（MOG）和髓鞘碱性蛋白（MBP）的抗体反应与人类白细胞抗原（HLA）II类等位基因之间的关联。我们发现MS患者对MOG和MBP的抗体反应显著增加，与无症状亲属相比无差异。HLA DRB104与MS患者对MOG的IgM反应性相关，而DRB115和DRB5与无症状亲属中的抗MOG IgA相关。我们得出结论，对MOG和MBP的抗体反应取决于家族背景。此外，针对MOG的体液免疫反应部分受某些HLA II类等位基因的控制。
