用于RNA的合理配体设计：静态结构和构象灵活性在靶标识别中的作用。
Rational ligand design for RNA: the role of static structure and conformational flexibility in target recognition.
作者信息
Hermann Thomas
机构信息
Department of Computational Chemistry and Structure, Anadys Pharmaceuticals, Inc., 9050 Camino Santa Fe, San Diego, CA 92121, USA.
出版信息
Biochimie. 2002 Sep;84(9):869-75. doi: 10.1016/s0300-9084(02)01460-8.
Abstract
The role of static structure and conformational flexibility in the recognition of RNA targets by small molecule ligands is discussed with emphasis on the natural aminoglycoside antibiotics and their promiscuity in RNA target binding. A brief overview is given of previous efforts to design simplified aminoglycoside derivatives targeted at the bacterial decoding site RNA.
摘要
讨论了静态结构和构象灵活性在小分子配体识别RNA靶标中的作用，重点是天然氨基糖苷类抗生素及其在RNA靶标结合中的混杂性。简要概述了先前针对细菌解码位点RNA设计简化氨基糖苷衍生物的工作。
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