Khrenov Alexey V, Ananyeva Natalya M, Griffin John H, Saenko Evgueni L
Department of Biochemistry, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA.
Trends Cardiovasc Med. 2002 Oct;12(7):317-24. doi: 10.1016/s1050-1738(02)00182-2.
Atherosclerosis is a disease recognized as the main cause of death in industrial countries. The current paradigm establishes thrombosis to be the major reason for complications of atherosclerosis, such as myocardial infarction and stroke, and the major factor responsible for atherosclerosis-related mortality. Development of adequate treatment of patients with risk of atherothrombosis requires the comprehensive understanding of mechanisms underlying coagulation processes at the site of atherosclerotic lesion. The present review discusses contribution of the extrinsic and intrinsic pathways of blood coagulation in thrombogenicity of atherosclerotic plaque and factors determining the overall procoagulant/anticoagulant balance.
动脉粥样硬化是一种在工业化国家被公认为主要死因的疾病。当前的范式认为血栓形成是动脉粥样硬化并发症（如心肌梗死和中风）的主要原因，也是动脉粥样硬化相关死亡率的主要因素。要开发针对动脉粥样硬化血栓形成风险患者的适当治疗方法，需要全面了解动脉粥样硬化病变部位凝血过程的潜在机制。本综述讨论了凝血的内源性和外源性途径在动脉粥样硬化斑块血栓形成中的作用以及决定整体促凝/抗凝平衡的因素。
