Sharma Jaimala, Sharma Radha
Department of Zoology, University of Rajasthan, Jaipur 302004, India.
Phytother Res. 2002 Dec;16(8):785-6. doi: 10.1002/ptr.1069.
Centella asiatica, has a considerable reputation in the Indian system of medicine. It is a rasayan (general tonic), brain tonic, improves memory and strengthens the CNS. In view of its multifarious uses, the plant extract was tested for its radioprotective properties. A sublethal dose of Co 60 gamma radiation, i.e. 8 Gy was selected for the purpose. Animals were divided into two groups. The whole bodies were irradiated with Co 60 gamma radiation externally, with and without drug extract. The drug extract was given orally at different doses and for different time intervals. The dose that was most effective against radiation was 100 mg/kg body weight. This dose increased the survival time of the mice significantly. Body weight loss of the animals in the drug treated group was significantly less in comparison with the animals that were given radiation only. The causes and mechanism of protection and other aspects need further investigations.
积雪草在印度医学体系中颇负盛名。它是一种滋补药（一般滋补剂）、脑滋补剂，能改善记忆力并增强中枢神经系统。鉴于其多种用途，对该植物提取物的辐射防护特性进行了测试。为此选择了亚致死剂量的钴60γ辐射，即8戈瑞。将动物分为两组。对动物全身进行外部钴60γ辐射，一组给予药物提取物，另一组不给予。以不同剂量和不同时间间隔口服给予药物提取物。对辐射最有效的剂量是100毫克/千克体重。该剂量显著延长了小鼠的存活时间。与仅接受辐射的动物相比，药物治疗组动物的体重减轻明显更少。保护的原因和机制以及其他方面需要进一步研究。
