Sharma C, Aulerich R J, Render J A, Reimers T, Rottinghaus G E, Kizilkaya K, Bursian S J
Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA.
Vet Hum Toxicol. 2002 Dec;44(6):324-7.
Ergot alkaloids are-synthesized by fungi of the Claviceps family that infect rye as well as other cereals and grains. Since a portion of the ranch mink diet is cereal, mink are at a risk of being exposed to ergot alkaloids. This study was performed to determine the reproductive toxicity of ergot alkaloids derived from ergot-contaminated oats in mink. Four groups of 12 female mink each were fed diets containing 0, 3, 6 or 12 ppm ergot alkaloids from 2w prior to the breeding season until the kits were approximately 33-d old (133 d). Females were mated with untreated males. Ergo talkaloids caused a transient decrease in feed consumption, but body weights were unaffected. The gestation period of the mink in the 6 ppm group was longer compared to controls. The number of mink whelping varied significantly with 9 mink whelping each in the control and 3 ppm groups compared to 4 mink in the 6 ppm group and 1 in the 12 ppm group. Ergot alkaloids had a significant effect on kit survivabilitywith no kits surviving in the 12 ppm group. Serum prolactin was significantly depressed in the 3 ergot alkaloid groups compared to the control group. This study indicated that ingestion of ergot alkaloids at 3 ppm or higher resulted in reproductive toxicity in mink.
麦角生物碱由麦角菌属真菌合成，这些真菌会感染黑麦以及其他谷物。由于牧场水貂的部分日粮是谷物，水貂有接触麦角生物碱的风险。本研究旨在确定受麦角污染的燕麦中提取的麦角生物碱对水貂的生殖毒性。四组实验，每组12只雌性水貂，在繁殖季节前2周开始喂食含有0、3、6或12 ppm麦角生物碱的日粮，直至幼崽约33日龄（133天）。雌性水貂与未处理的雄性水貂交配。麦角生物碱导致采食量短暂下降，但体重未受影响。与对照组相比，6 ppm组水貂的妊娠期更长。产仔水貂的数量差异显著，对照组和3 ppm组各有9只水貂产仔，而6 ppm组有4只，12 ppm组有1只。麦角生物碱对幼崽的存活率有显著影响，12 ppm组没有幼崽存活。与对照组相比，3个麦角生物碱组的血清催乳素水平显著降低。本研究表明，摄入3 ppm或更高剂量的麦角生物碱会导致水貂生殖毒性。
