益生菌与健康：新事实与新观点。

Probiotics and health: new facts and ideas.

作者信息

Marteau Philippe, Seksik Philippe, Jian Raymond

机构信息

Gastroenterology Department, European Hospital Georges Pompidou, Assistance Publique des Hôpitaux de Paris & Paris V University, Paris, France.

出版信息

Curr Opin Biotechnol. 2002 Oct;13(5):486-9. doi: 10.1016/s0958-1669(02)00368-3.

DOI:10.1016/s0958-1669(02)00368-3

PMID:12459342

Abstract

Many trials on probiotics are now published that use established methods to demonstrate their clinical efficacy. Convincing progress has been made in the field of inflammatory bowel disease and allergy prevention in infants. Experimental studies show clear differences (and even sometimes opposite effects) between apparently closely related probiotics and suggest new mechanisms for the observed effects, such as immunostimulation by bacterial DNA and interaction with Toll-like receptors and dendritic cells in the gastrointestinal tract.

摘要

现在已经发表了许多关于益生菌的试验，这些试验采用既定方法来证明其临床疗效。在婴儿炎症性肠病和过敏预防领域已经取得了令人信服的进展。实验研究表明，看似密切相关的益生菌之间存在明显差异（有时甚至有相反的效果），并提出了观察到的效果的新机制，例如细菌DNA的免疫刺激以及与胃肠道中Toll样受体和树突状细胞的相互作用。