Braude Peter, Pickering Susan, Flinter Frances, Ogilvie Caroline Mackie
Centre for Preimplantation Genetic Diagnosis, Thomas Guy House, Guy's Hospital, London SE1 9RT, UK.
Nat Rev Genet. 2002 Dec;3(12):941-53. doi: 10.1038/nrg953.
Preimplantation genetic diagnosis (PGD) is an evolving technique that provides a practical alternative to prenatal diagnosis and termination of pregnancy for couples who are at substantial risk of transmitting a serious genetic disorder to their offspring. Samples for genetic testing are obtained from oocytes or cleaving embryos after in vitro fertilization. Only embryos that are shown to be free of the genetic disorders are made available for replacement in the uterus, in the hope of establishing a pregnancy. PGD has provided unique insights into aspects of reproductive genetics and early human development, but has also raised important new ethical issues about assisted human reproduction.
植入前基因诊断（PGD）是一项不断发展的技术，为那些极有可能将严重遗传病传给后代的夫妇提供了一种切实可行的替代产前诊断和终止妊娠的方法。基因检测样本取自体外受精后的卵母细胞或分裂期胚胎。只有那些被证明没有遗传病的胚胎才会被植入子宫，以期成功受孕。PGD为生殖遗传学和人类早期发育方面提供了独特的见解，但也引发了有关人类辅助生殖的重要新伦理问题。
