Hideshima Teru, Anderson Kenneth C
Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.
Nat Rev Cancer. 2002 Dec;2(12):927-37. doi: 10.1038/nrc952.
Multiple myeloma remains largely incurable despite conventional and high-dose therapies, and so novel biologically based treatment approaches are urgently required. Recent studies have characterized the molecular mechanisms by which multiple myeloma cell-host bone-marrow interactions regulate tumour cell growth, survival and migration in the bone-marrow microenvironment. These studies have not only enhanced our understanding of disease pathogenesis, but have also provided the framework for a new treatment model that targets the multiple myeloma cell in its bone-marrow microenvironment to overcome drug resistance and improve patient outcome.
尽管采用了传统疗法和高剂量疗法，多发性骨髓瘤在很大程度上仍然无法治愈，因此迫切需要基于生物学的新型治疗方法。最近的研究已经阐明了多发性骨髓瘤细胞与宿主骨髓相互作用在骨髓微环境中调节肿瘤细胞生长、存活和迁移的分子机制。这些研究不仅加深了我们对疾病发病机制的理解，还为一种新的治疗模式提供了框架，该模式针对骨髓微环境中的多发性骨髓瘤细胞，以克服耐药性并改善患者预后。
