溶瘤病毒

Oncolytic viruses.

作者信息

Chiocca E Antonio

机构信息

Molecular Neuro-Oncology Laboratories, Neurosurgery Service, Massachusetts General Hospital, East Building, 13th Street, Bldg 149, Charlestown, Massachusetts 02129, USA. chioccahelix.mgh.harvard.edu.

出版信息

Nat Rev Cancer. 2002 Dec;2(12):938-50. doi: 10.1038/nrc948.

DOI:10.1038/nrc948

PMID:12459732

Abstract

Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile, and can be modified to direct their cytotoxicity towards cancer cells. These viruses are known as oncolytic viruses. How are viruses engineered to become tumour specific, and can they be used to safely treat cancer in humans?

摘要

尽管病毒的细胞毒性作用通常从致病性角度来看待，但有可能将这种活性用于治疗目的。病毒基因组具有高度的通用性，可以进行改造，使其细胞毒性作用针对癌细胞。这些病毒被称为溶瘤病毒。病毒是如何被设计成肿瘤特异性的，以及它们能否被用于安全地治疗人类癌症呢？